Molecular origin of continuous dark noise in rod photoreceptors
نویسندگان
چکیده
منابع مشابه
The molecular mechanism of thermal noise in rod photoreceptors.
Spontaneous electrical signals in the retina's photoreceptors impose a limit on visual sensitivity. Their origin is attributed to a thermal, rather than photochemical, activation of the transduction cascade. Although the mechanism of such a process is under debate, the observation of a relationship between the maximum absorption wavelength (λ(max)) and the thermal activation kinetic constant (k...
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1 Roberts, J L and Prltchett, D (1984) Frends NeuroSc: 7, 105-I07 2 Mason, A J , Evans, B A , Cox, D R , Shine, J and Richards, R I (1983) Nature (London) 303, 300-307 3 0 w e n , M C ,Brennan , S O , L e w l s , J H and Carrell, R W (1983) N Engl J Med 309, 694--698 4 Brennan S O and Can'ell, R W (1978) Nature (London) 274,908--909 5 Abdo, Y , Rousseaux, J and Dautrevaux M (1981) FEBS Lett 131...
متن کاملMolecular properties of the cGMP-gated channel of rod photoreceptors
The cGMP-gated channel of the rod photoreceptor cell plays a key role in phototransduction by controlling the flow of Na+ and Ca2+ into the outer segment in response to light-induced changes in cGMP concentrations. The rod channel is composed of two homologous subunits designated as alpha and beta. Each subunit contains a core region of six putative membrane spanning segments, a cGMP binding do...
متن کاملThe evolution of rod photoreceptors.
Photoreceptors in animals are generally of two kinds: the ciliary or c-type and the rhabdomeric or r-type. Although ciliary photoreceptors are found in many phyla, vertebrates seem to be unique in having two distinct kinds which together span the entire range of vision, from single photons to bright light. We ask why the principal photoreceptors of vertebrates are ciliary and not rhabdomeric, a...
متن کاملCa2+ Dependence of Dark- and Light-Adapted Flash Responses in Rod Photoreceptors
Light adaptation is thought to be orchestrated by a Ca2+ feedback signal that desensitizes the response by speeding recovery. To evaluate the role of Ca2+ in adaptation, we compared the effect of lowered Ca2+ on response properties in darkness and during adaptation. Internal Ca2+ was reduced from its normal resting dark level (535 nM) by either background illumination or exposure to Ringer's so...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1996
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(96)79448-1